Answer the 4 Parts to: Aldol Reaction
Use this picture of Aldol Reaction of Cyclopentanone to answer questions 1 and 2
1. During step 3, what type of overall reaction occurs in the Aldol reaction?
(A) Acid Catalysed dehydration
(B) Acid Catalysed Aldol addition
(C) Electrophilic addition
(D) Acid catalysed enolization
Answer: (A) Acid Catalysed dehydration
2. Which functional group is responsible for the formation of the stable conjugated enone?
Water
Hydroxy group
Acid catalyst
Carbonyl group
Answer: (D) Carbonyl group
True or False: Explain
3. In the presence of hydroxide, either propanal or acetaldehyde serve as a nucleophile in an aldol reaction.
Answer True
4. Either propanal or acetaldehyde can serve as an electrophile in an aldol reaction.
Answer: True
In the presence of hydroxide, each aldehyde can enolize to form a nucleophilic enolate anion. The enolate can react with an unionized aldehyde in the first step of an aldol condensation. The unionized aldehyde is an electrophile in this reaction.
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